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Nature's Garden Natural Foods & Shoes

Nature's Garden Natural Foods & Shoes

Berks County's biggest natural food store. We provide solutions to your health problems.

Nature's Garden Natural Foods & Shoes

1 day ago

Nature's Garden Natural Foods & Shoes
Excess added sugar does far more than just contribute to weight gain: it spikes insulin levels, fuels chronic inflammation that can worsen brain health and support cancer growth, disrupt the healthy balance of gut bacteria, and speed up glycation a process that damages cells and accelerates aging at the cellular level. ... See MoreSee Less

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Nature's Garden Natural Foods & Shoes

2 days ago

Nature's Garden Natural Foods & Shoes
Berberine has attracted considerable scientific interest because it acts on multiple cellular pathways involved in cancer development rather than targeting a single protein. Extensive laboratory (in vitro) studies have demonstrated cytotoxic activity against numerous cancer cell lines, including breast, colorectal, lung, liver, prostate, pancreatic, ovarian, gastric, and leukemia cells. Researchers have found that berberine induces apoptosis, or programmed cell death, by disrupting mitochondrial function, increasing pro-apoptotic proteins such as Bax, reducing anti-apoptotic proteins such as Bcl-2, and activating caspases. It also causes cell cycle arrest, typically at the G0/G1 or G2/M phases, preventing cancer cells from replicating and proliferating. In addition, berberine suppresses several signaling pathways associated with tumor growth and survival, including PI3K/Akt/mTOR, MAPK/ERK, NF-κB, and Wnt/β-catenin, while inhibiting angiogenesis and metastatic processes. Despite these promising laboratory findings, the results have not translated into an approved cancer treatment for humans. A major limitation is berberine's poor oral bioavailability, with less than 1–5% of an ingested dose reaching systemic circulation because of limited intestinal absorption and extensive first-pass metabolism. Consequently, the concentrations used in laboratory experiments cannot be achieved safely with standard oral supplements. Current research is focused on improving delivery using nanoparticles and evaluating berberine as an adjuvant to conventional chemotherapy, where it may enhance treatment effectiveness and reduce drug resistance. ... See MoreSee Less

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Nature's Garden Natural Foods & Shoes

4 days ago

Nature's Garden Natural Foods & Shoes

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